Cytoplasmic Viral Replication Complexes
نویسندگان
چکیده
منابع مشابه
Unraveling the Structure of Viral Replication Complexes at Super-Resolution
During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components. These structures were first described over a century ago and originally termed "X-bodies," as their function was not immediately appreciated. Whilst some inclusion bodies may represent cytopathic by-products of viral protein over-accumulation, X-bodies have emerged as virus "f...
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The initiation and termination of vaccinia virus postreplicative transcription have been reported to require cellular proteins, some of which are believed to be nuclear proteins. Vaccinia virus replicates in the cytoplasmic compartment of the cell, raising questions as to whether vaccinia virus has access to nuclear proteins. This was addressed here by following the fate of several nuclear prot...
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by a single A→U point mutation3. Both the benzimidazole derivative and the mutation reduce the production of viral proteins by approximately 80%, likely by preventing formation of the complete 80S eukaryotic ribosome. Hence this small molecule does not function by competitively inhibiting the interaction between the IRES and its target. Instead, it affects IRESdriven viral protein synthesis by ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2010
ISSN: 1931-3128
DOI: 10.1016/j.chom.2010.06.010